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Briganix 90mg Tablets : Generic Brigatinib




Medicine Detail


Brand Name: Briganix 

International Brand Name: Alunbrig 

Ingredient: Brigatinib 90mg 

Manufactured By: Beacon Pharmaceuticals Ltd. 

Form: Tablets 

Packing: Pack of 30 Tablets 

Country Origin: Bangladesh 

* Bangladesh medicine is not for sale in India. 

布加替尼 / Bujitabin,孟加拉国,对克唑替尼耐药后的首选药物 

尽管克唑替尼已显着提高了非小细胞肺癌患者的生存率,但不幸的是,几乎所有针对ALK或EGFR基因突变的初始靶向疗法都不可避免地会产生耐药性问题,其中大部分是由于耐药性在12个月内发展而复发的。这种抗性是治疗上的挑战,并导致了第二代ALK抑制剂的发展。

布加替尼 (Brigatinib) 刚刚克服了ALK突变体对crizotinib的耐药性。它是酪氨酸酶抑制剂,对多种激酶(包括ALK,ROS1,胰岛素样生长因子-1受体,Flt-3)和表面生长因子受体(EGFR)缺失和点突变具有活性。布匹他滨在体外对克唑替尼的抑制作用是克唑替尼的12倍,并且对ALK突变体的耐药性较高,因此可用于治疗克唑替尼用于转移性非小细胞肺癌疾病进展或不耐受的ALK阳性患者。
从每天90 mg的起始剂量开始,连续7天每天90 mg口服;

如果没有严重的副作用或不耐受,则将剂量调整为7天后每天180 mg。

如果由于不良反应(例如服药后遗漏药物或呕吐)而使药物暂停14天或更长时间,则应连续7天每天服用一次90毫克的剂量,然后再重新给药,然后增加先前的耐受剂量。

该药物应完全吞下,不要压碎或咀嚼。它可以带或不带食物一起服用。

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Tags: Generic Brigatinib, Briganix Tablets, lung cancer medicines

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