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Nublast 20 mg Capsule




Medicine Detail


Brand: Nublast Capsules

Composition: Temozolomide Capsule 20 mg

Manufacturer: Zydus

Packing: Pack of 5 Capsules

WHAT IS NUBLAST CAPSULES?

Temozolomide interferes with the development of cancer cells, slowing their growth and spread in the body. Temozolomide is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug.  This medication is classified as an "alkylating agent.

USES OF NUBLAST CAPSULES:

Temozolomide is used for the treatment of anaplastic astrocytoma, glioblastoma multiforme (GBM) (types of brain tumors). Temozolomide is classified as an alkylating agent.  Alkylating agents are most active in the resting phase of the cell.  These drugs are cell-cycle non-specific. Temozolomide is similar to the drug dacarbazine.  It acts as a "pro-drug" meaning it needs to be transformed to its active (cancer fighting) form by the body's metabolism.

POSSIBLE SIDE EFFECTS:

seizure (convulsions); fever, chills, dry cough, feeling short of breath;
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
low white blood cell counts--fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing; or
liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

COMMON SIDE EFFECTS MAY INCLUDE:

bruising, skin rash; loss of movement on one side of the body; nausea, vomiting, loss of appetite;
diarrhea, constipation; headache, tired feeling, memory problems; dizziness, weakness, loss of coordination;
sleep problems (insomnia); low white blood cell counts (fever, flu symptoms); or hair loss.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Nublast are Rash, Headache, Dizziness, Convulsion, Coordination disorder, Insomnia (difficulty in sleeping), Vomiting, Weakness, Nausea, Loss of appetite, Hair loss, Fatigue, Fever, Diarrhoea, Memory loss, Constipation, Hemiparesis (weakness on one side of the body.

DRUGS INTERACTIONS: 

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nublast 20 mg Capsule is to be taken empty stomach.

Nublast 20 mg Capsule is an anti-cancer medication. It enters the brain tissues and works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

DRUGS PRECAUTIONS:

Swallow full tablets on an empty stomach, one hour before your meal.

Avoid being near people who are sick or have infections. Consult your doctor if you develop symptoms of opportunistic infections (such as Pneumocystis jirovecii pneumonia) and reactivation of infections (such as hepatitis B virus) Using temozolomide may increase your risk of developing certain types of bone marrow cancer. Be aware about your specific risk.

You may be given medication to prevent nausea or other side effects while you are receiving temozolomide.

Your blood will be tested frequently during treatment to monitor the side effects of temozolomide on your blood cells as you may have a small risk of other changes in blood cells, including leukemia.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

Do not drink alcohol while taking temozolomide.

Do not drive or operate machinery while using temozolomide as it may make you tired or sleepy.

Both male and female patients should take effective contraceptive precautions during and after 6 months of treatment. Male patients should seek advice on conservation of sperm prior to treatment as temozolomide treatment may cause infertility.

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