Xgeva Denosumab Injection 120 mg

Medicine Detail

Brand Name: Xgeva
Contents: Denosumab Solution
Manufactured by: Amgen
Marketed by: Glaxo SmithKline (GSK)
Strength: 120 mg / 1.7mL
Form: Solution for Injection
Packing: Pack of 1 Vial


Xgeva is a monoclonal antibody that works as a RANK ligand (RANKL) inhibitor. This medication is classified as a "bone-modifying agent". Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage.


Denosumab is used to prevent bone fractures and other skeletal conditions in people with tumors that have spread to the bone. It is also used to treat giant cell bone tumor in adults and teenagers with fully matured bone structure. It is also used to treat high blood levels of calcium caused by cancer, when other medicines such as pamidronate or zoledronic acid have been used without success.


Along with its needed effects, denosumab (the active ingredient contained in Xgeva) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Get emergency medical help if you have any of these signs of an allergic reaction: itching, rash, hives; difficult breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat.


A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. 
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.


This medication may cause infections that in some cases are serious and require hospitalization. Contact your doctor at once if you develop signs of an infection such as fever, abdominal pain, earache, painful urination, or blood in the urine, or if you notice a red, swollen, or tender area on the skin. People who are taking medications that suppress the immune system (e.g., prednisone, azathioprine, anticancer medications) or who have a suppressed immune system may be more at risk of developing infections.

Denosumab may cause problems with your upper or lower jaw. You may be at a higher risk of these problems if you have cancer that has spread to the bones, are taking certain medications (e.g., prednisone, anticancer medications), are having radiation treatments, have poor oral hygiene, or are having a tooth extracted. Your doctor may recommend that you see a dentist before starting this medication. It is important to practice good oral hygiene while taking this medication.


His safety and effectiveness of using this medication have not been established for children. Denosumab is only recommended for adolescents with giant cell tumour of bone whose bones have stopped growing. Denosumab has not been studied in children and adolescents with other cancers that have spread to bone.
 Tell your doctor or prescribe about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescribe know if you use them.

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