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Kadcyla Trastuzumab Emtansine 160 mg Injection




Medicine Detail


Brand Name: Kadcyla

Composition: Trastuzumab Emtansine 160 mg

Manufactured by: F. Hoffman-La Roche AG

Form: Injection

Packing: Pack of 1 Vial

WHAT IS KADCYLA INJECTION?

Kadcyla (ado-trastuzumab emtansine) is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Kadcyla is approved to treat HER2-positive breast cancer that has spread to other parts of the body (metastatic breast cancer) after prior treatment with trastuzumab (Herceptin) and a taxane.

USES OF KADCYLA INJECTION:

Kadcyla is used to treat a certain type of breast cancer that has spread to other parts of the body.

Kadcyla is usually given after other cancer medications have been tried without success.

Kadcyla (ado-trastuzumab) should not be used in place of Herceptin (trastuzumab).

POSSIBLE SIDE EFFECTS:

Kadcyla can harm your liver. Call your doctor at once if you have upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

Along with its needed effects, ado-trastuzumab emtansine (the active ingredient contained in Kadcyla) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

COMMON SIDE EFFECTS MAY INCLUDE:

This drug has caused very serious (rarely fatal) bleeding. Get medical help right away if you develop symptoms of very serious bleeding, including: weakness on one side of the body, slurred speech, vision changes, confusion, severe stomach/abdominal pain, trouble breathing, vomit that is bloody or looks like coffee grounds, black/tarry stool.

This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as fever, chills, persistent sore throat and cough).

This medication can sometimes cause a serious infusion reaction with serious lung problems. Immediately tell your doctor of the following side effects that occur while this drug is being given or within 24 hours after your treatment is finished, such as chills, fever and flushing, wheezing, shortness of breath, nausea, headache, dizziness, fainting, rash, and weakness.

DRUGS PRECAUTIONS:

Before taking ado-trastuzumab emtansine, tell your doctor or pharmacist if you are allergic to it; or to other mouse protein medications; or if you have any other allergies. This product may contain inactive ingredients which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: previous cancer treatments (including radiation therapy to the chest), current infection, heart disease, high blood pressure, lung problems and previous severe reaction to monoclonal antibody treatment, liver disease (including a rare liver condition called nodular regenerative hyperplasia).

DRUGS INTERACTIONS:

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/non-prescription drugs and herbal products) and share it with your doctor and pharmacist. Does not start, stop, or change the dosage of any medicines without your doctor's approval.

If you will be using an anthracycline (such as doxorubicin) after stopping ado-trastuzumabemtansine treatment, if possible, wait at least 7 months.

Other medications can affect the removal of ado-trastuzumab emtansine from your body, which may affect how ado-trastuzumab emtansine works. Examples include azole antifungals (such as itraconazole, ketoconazole), clarithromycin, HIV protease inhibitors (such as atazanavir, ritonavir), nefazodone, telithromycin, among others.

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